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Caveats on grapefruit

2017/07/23 03:10

Caveats on grapefruit
As with any medication, there are considerations about the use of grapefruit with medications. More than 50 prescription and over-the-counter drugs are affected by grapefruit juice, including some of the most commonly prescribed medications. This list includes a number of medications used to treat high cholesterol, high blood pressure, depression, pain, erectile dysfunction, and allergies.


Grapefruit contains a substance that inhibits the enzyme called CYP3A4. This powerful enzyme breaks down numerous medications such as the cholesterol-lowering drug, Lipitor. Patients who take Lipitor, or some antidepressant medication, and eat grapefruit, can have toxic levels of the medications because the grapefruit inhibits CYP34A.


So what are patients to do>> Check with your healthcare provider or pharmacist to find out about your specific drug. All new medications are tested for drug interactions, including grapefruit juice, before they are approved by the U.S. Food and Drug Administration (FDA). When you order medications in the mail or pick them up at your local pharmacy, you should receive a patient information sheet, which will let you know if your drug is affected by grapefruit juice. Some pharmacies may also put a warning label on your medication bottle. If you are not sure, ask the pharmacist.


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